Publication:
Quantitative Surface Analysis of a Binary Drug Mixture—Suppression Effects in the Detection of Sputtered Ions and Post-Ionized Neutrals
Gabriel Karras, Nicholas P. Lockyer
Journal of The American Society for Mass Spectrometry (2014)
Author Archives: Alex Henderson
“It’s good, but it’s not right!…” How to validate your model
Alex gave a presentation entitled “It’s good, but it’s not right!…” How to validate your model at the UK Surface Analysis Forum‘s (UKSAF) Workshop on Multivariate Analysis held at the University of Nottingham, 8 January 2014.
The purpose of the workshop was to introduce users of surface analysis technologies to multivariate analysis with a combination of theory and demonstration.
The presentation covered validation of multivariate models, how to get the most out of them and how to avoid various pitfalls in the data treatment. The slides for the talk can be found here.
Awards winning poster!
At the recent SciX Conference in Milwaukee USA, Jo walked away with not one, but two awards for best poster! Both the Society for Applied Spectroscopy (SAS) and the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) judged Jo’s work on “ToF-SIMS and Raman microspectroscopy as tools for probing lipid saturation in acute myeloid leukaemia cells treated with a novel combination therapy” to be outstanding and awarded her certificates and cash.
We are very grateful to the Royal Society of Chemistry, Manchester & District Local Section for sponsoring Jo’s travel to the conference.
Welcome Ewa!
We welcome Ewa Szula to the group as a new PhD student working on the metabolic profiling of mammalian cells.
Welcome Kat!
We welcome Katherine Hollywood to the group as a post-doctoral researcher. Kat will be working on the application of single cell metabolite profiling to optimisation of stem cell bioprocessing as part of a collaboration with Alan Dickson, Karen Cosgrove, Mark Dunne and Roy Goodacre.
Paper – Peptide characterisation using Argon clusters
Publication:
Peptide structural analysis using continuous Ar cluster and C60 ion beams
Satoka Aoyagi, John S. Fletcher, Sadia Sheraz (Rabbani), Tomoko Kawashima, Irma Berrueta Razo, Alex Henderson, Nicholas P. Lockyer, John C. Vickerman
Analytical and Bioanalytical Chemistry (2013) doi: 10.1007/s00216-013-7139-z
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Welcome Huriyyah!
We welcome Huriyyah Alturaifi to the group as a new PhD student working on polyatomic SIMS.
John Vickerman: A Celebration of a Career in SIMS
In 2013, John celebrates his 70th birthday. To mark this occasion, and a career devoted to the development of secondary ion mass spectrometry – including instrumentation, theory and applications – we invite you to a special scientific meeting on October 11 in the Manchester Institute of Biotechnology.
We are delighted to have an international programme of outstanding quality, with confirmed contributions from the following speakers:
- David Castner (University of Washington)
- Arnaud Delcorte (Universite Catholique de Louvain)
- Barbara Garrison (Pennsylvania State University)
- Ian Gilmore (National Physical Laboratory)
- Ron Heeren (FOM-AMOLF, The Netherlands)
- Nick Lockyer (University of Manchester)
- Nick Winograd (Pennsylvania State University)
There will be a celebration dinner and we hope that as many attendees as possible will be able to join us for that.
Registration for the meeting is available here: http://www.massspecmanchester.org/symposia/registration/
Please mark October 11 in your diaries! If you have any questions, please contact Graham Leggett (graham.leggett@sheffield.ac.uk) or Nick Lockyer (nick.lockyer@manchester.ac.uk).
Further information can be found on the MassSpectrometry@Manchester site.
Michael Barber Centre for Mass Spectrometry
Nick has taken over as Acting Director of the Michael Barber Centre for Mass Spectrometry
Paper – Water cluster primary beams
Publication (open access):
Enhancing Secondary Ion Yields in Time of Flight-Secondary Ion Mass Spectrometry Using Water Cluster Primary Beams
Sadia Sheraz née Rabbani, Andrew Barber, John S. Fletcher, Nicholas P. Lockyer, and John C. Vickerman
Analytical Chemistry 85(12) (2013) 5654–5658 doi: 10.1021/ac4013732
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SIMS and Pharmacy talk
Nick gave an invited talk on Imaging Biosystems using Secondary Ion Mass Spectrometry to industrialists and academics at the Royal Society of Chemistry in London, organised by the Joint Pharmaceutical Analysis Group and The Drug Metabolism Discussion Group. The title of the meeting was ‘New approaches in bioanalysis and analytical toxicology’.
Travel award for Jo
Jo has been awarded a bursary from the Royal Society of Chemistry towards her attendance at an international conference.
At the meeting she will present her results on mammalian cell characterization. This is part of her PhD project on Lipidomic and Metabolomic Imaging of Biological Response Mechanisms in Tissues and Single Cells involving Raman and IR spectroscopies in addition to LC-MS and SIMS analyses.
Analytical Chemistry cover art
The issue of Analytical Chemistry containing John and John’s review on Secondary Ion Mass Spectrometry: Characterizing Complex Samples in Two and Three Dimensions has artwork generated by John Fletcher on the cover.
Paper – Challenges of ToFSIMS for metabolomics
Publication:
Evaluating the challenges associated with time-of-flight secondary ion mass spectrometry for metabolomics using pure and mixed metabolites
John S. Fletcher, Helen L. Kotze, Emily G. Armitage, Nicholas P. Lockyer, John C. Vickerman
Metabolomics (2012) doi: 10.1007/s11306-012-0487-4 (2012)
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Paper – Imaging of metabolites
Publication:
Imaging of metabolites using secondary ion mass spectrometry
Emily G. Armitage, Helen L. Kotze, Nicholas P. Lockyer
Metabolomics 9 (2013) 102-109