Professor of Physical Chemistry
nick.lockyer @ manchester.ac.uk
tel: +44 (0)161 275 1013
My research interests focus on the development and application of surface analysis and chemical imaging particularly ToF-SIMS and laser-based mass spectrometry. There are three themes to this research: fundamentals, instrument development and applications research. The Life Sciences provide an exciting field in which to develop new applications, which in turn drive developments in methodology and technology. We are currently seeking to exploit these advances through a variety of collaborations with fellow academics, industrial partners and healthcare professionals.
Research topics: Analytical Chemistry; Instrumentation; Chemical imaging; Ion-solid interactions; Laser-matter interactions; Materials characterisation
Current Research Projects
- Development of ToF-SIMS instrumentation and methodology for 2D and 3D chemical imaging
Collaborators: Ionoptika Ltd (Southampton), Ian Gilmore (National Physical Laboratory), Arnaud Delcorte (Université catholique de Louvain)
- Laser post-ionisation of sputtered neutrals
Collaborators: Zoltan Takats (Rosalind Franklin Institute & Imperial College), Josephine Bunch (National Physical Laboratory & Imperial College)
- Ambient mass spectrometry in biotechnology and biomedicine
Collaborators: P. Barran, E. Takano (UoM, Department of Chemistry), Waters Corp.
- The application of ToF-SIMS in cancer biology, diagnosis and therapy
Collaborators: K. Williams (UoM School of Pharmacy & Pharmaceutical Sciences); A. McMahon (UoM School of Cancer Studies and Wolfson Molecular Imaging Centre); P. Gardner (UoM, School of Chemical Engineering & Analytical Science), N. Clarke & M. Brown (UoM School of Cancer and Enabling Sciences & CRUK Paterson Institute for Cancer Research)
Recent Funding Sources
EPSRC, BBSRC, CRUK, Wellome Trust
Recent Publications [All Publications]
- N.P. Lockyer, Laser Post-ionisation for Elemental and Molecular Surface Analysis in ToF-SIMS – Surface Analysis by Mass Spectrometry, Second Edition, Eds. J.C. Vickerman and D. Briggs, SurfaceSpectra (Manchester) and IM Publications (Chichester)
- N.P. Lockyer “Static Secondary Ion Mass Spectrometry for Biological and Biomedical Research” Methods Mol. Biol. 369 (2007) 543-567
- INVITED, “Improved bioanalysis using GCIB SIMS and laser post-ionisation”, 14th International Symposium on Atomic Level Characterizations for New Materials and Devices (ALC’22) Okinawa, Japan. Oct 2022.
- KEYNOTE “Multimodal Mass Spectrometry and Optical Imaging of a Neuroinflammation Model‘ 42nd British Mass Spectrometry Society Conference, Manchester, September 2022.
- INVITED “Advances in ToF-SIMS using massive gas cluster ion beams” UK Surface Analysis Forum Manchester July 2022.