Dr Joanna Denbigh

Joanna Denbigh

Visiting Researcher

Lecturer in Pharmacology
School of Environment and Life Sciences
University of Salford
t: +44 (0) 161 295 8152

j.l.denbigh @ salford.ac.uk

  • MChem in Chemistry, University of Salford
  • Analytical Chemist, GlaxoSmithKline
  • Training and Technical Consultant, Crawford Scientific
  • Applications Chemist, Waters
  • Associate Lecturer in the School of Forensic and Investigative Sciences, University of Central Lancashire
  • Senior Applications Scientist and Training Coordinator, Thermo Fisher Scientific


I have had many years industrial experience in the application of HPLC, GC and MS covering a wide variety of analytical applications.

I graduated from the University of Salford with a Masters Degree in Chemistry, during which time I was granted a MRSEC scholarship enabling me to carry out a 3 month research project at the University of Nebraska, USA

During my degree, I also spent one year working with triple quadrupole Mass Spectrometry in the Drug Metabolism department at Pfizer, UK.

On leaving University, I entered industry as an Analytical Chemist for GlaxoSmithKline in Stevenage. My position in Chemical Development was to support the analytical requirements of projects from early to late phase.  This role required coordinating the full analysis required, in particular HPLC assays and impurity techniques with UV and Mass Spectrometry detection, GC/MS, appearance tests and sample preparation techniques.  I worked closely with project organic chemists and carried out significant method development on new synthetic compounds to support scale-up lab work and pilot plant campaigns in a GMP environment.

Following my time at GSK, I moved into a more educational and problem solving role as a Training and Technical Consultant for Crawford Scientific. This took me into many different industries where I provided training and analytical solutions, developing an understanding of the challenges surrounding analysis in the petrochemical, tobacco, fine chemicals, environmental and pharmaceutical industries whilst gaining a lot of experience in different vendors instruments, in particular Agilent and Waters.

This led me to Waters where I worked for 2 years as an Applications Chemist. I continued to work on a wide variety of small molecule analytical applications, such as impurity profiling with UPLC/ToF/MS technology. I developed a number of methods for analysis of low level impurities in drug substances, and also carried out research into the analysis of phospholipids with ion mobility spectrometry.

I was appointed as Associate Lecturer in the School of Forensic and Investigative Sciences at the University of Central Lancashire in November 2009 where I taught Analytical Chemistry across a variety of disciplines ranging from Forensic Chemistry to Fire Investigation, Toxicology and Pharmacy. I very much enjoyed bringing ‘real life’ industrial applications into the lecture theatre and lab classes and developing new and exciting course material for the students.

I returned to industry for one final year before commencing my PhD studies. My role was Senior Applications Scientist and Training Coordinator at Thermo Fisher Scientific in the Chromatography, Consumables and Speciality products group, based in Runcorn, UK. I developed LC and LC/MS applications in the lab, supported the launch of new chromatography products and coordinated all internal and external technical training activities for colleagues and customers alike.


I am undertaking research into Lipidomic and Metabolomic imaging of biological response mechanisms in tissues and cells. I aim to establish perturbations in a variety of cells as a consequence of pathological status or abiotic stress and subsequently localise and correlate such changes with imaging techniques, primarily Raman and SIMS. This will provide new insight into important biochemical processes associated with disease progression and environmental pollution.


2 Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques
Joanna L. Denbigh, David Perez-Guaita, Robbin R. Vernooij, Mark J. Tobin, Keith R. Bambery, Yun Xu, Andrew D. Southam, Farhat L. Khanim, Mark T. Drayson, Nicholas P. Lockyer, Royston Goodacre & Bayden R. Wood
Scientific Reports 7 (2017) 2649
1 ToF-SIMS as tool for profiling lipids in cancer and other diseases
J.L. Denbigh and N.P. Lockyer
Materials Science and Technology 31 (2014) 137-147


SIMS Europe 2012 Poster on A Multidimensional approach to the study of the lipidome and metabolome of the green Algae Chlamydomonas reinhardtii.

Thermo Scientific application notes

Determination of Beta Blockers from Urine Using SOLA CX and Accucore™ Core Enhanced Technology HPLC

This application note demonstrates the use of Thermo Scientific™ SOLA CX cartridges for the extraction of beta blockers from urine.

Capecitabine in Human Plasma Using SOLA and Accucore™ Core Enhanced Technology HPLC Column

This application note demonstrates the use of Thermo Scientific™ SOLA cartridges and plates for the extraction of capecitabine from human plasma.

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