Another paper from Matija’s PhD project, describing the benefits of water cluster SIMS  for cholesterol anaysis in tissues.  The publication appears in a topical colllection in Analytical and Bioanalytical Chemistry: From Organs to Single Cells – Frontiers in Mass Spectrometry Imaging, dedicated to Prof. Bernhard Spengler and honoring his
achievements in the field of bioanalytics.

Improvements in high-yield detection and localisation of cholesterol in murine brains using water cluster beam secondary ion mass spectrometry.

Lagator, M., Razo, I.B., Sheraz, S. and Lockyer, N.P.  Anal Bioanal Chem (2026). https://doi.org/10.1007/s00216-026-06448-8

Our new manuscript in the JVST B Special Issue celebrating the career of Prof. Jiro Matsuo has been selected as a Feature Article.  The paper is co-authored by Masters project student Lola Buttery.

Water-assisted secondary ion mass spectrometry using gas cluster ion beams

Sadia Sheraz, Lola Buttery, Nicholas P. Lockyer; Water-assisted secondary ion mass spectrometry using gas cluster ion beams. J. Vac. Sci. Technol. B 1 March 2026; 44 (2): 024004. https://doi.org/10.1116/6.0005135

A collaborative multi-modal investigation into cobalt ion implantation in nuclear graphite with implications for systematic evaluation of reactor safety and graphite waste management.

Structural recovery and chemical characterisation of ion-irradiated graphite for advanced nuclear applications

F.S. Altamimi, M. Coke, B.F. Spencer, S. Sheraz, E. Aradi, M. Lindley, N.P. Lockyer, R.J. Curry, S.J. Haigh, C.A. Sharrad, A.N. Jones, Carbon 2026, 252,121353,
https://doi.org/10.1016/j.carbon.2026.121353.

Our ongoing collaboration with the MS Imaging group at Rosalind Franklin Institute and Hua Tian at the University of Pittsburgh yields a new publication on advanced biomolecular analysis using water cluster SIMS.

The paper in the journal Analytical Chemistry is entitled Enhanced Formation of Multiply Charged Protein and Peptide Ions in SIMS Using Large Water Clusters and available here.

Another publication for Akhila, resulting from our collaboration with Syngenta, Waters Corp. and colleagues in the Manchester Institute of Biotechnology and The Department of Earth and Environmental Sciences:

Visualizing active fungicide formulation mobility in tomato leaves with Desorption Electrospray Ionisation Mass Spectrometry Imaging

DOI: 10.1039/D4AN01309C (Paper) Analyst, 2024, Advance Article

Our collaboration with the Medicines Discovery Catapult led by Irma results in a publication in a Special Issue of the International Journal of Molecular Sciences – Molecular Advances in Analytical Techniques for Biological and Medical Research: 2nd Edition

The paper is entitled Accumulation of Bioactive Lipid Species in LPS-Induced Neuroinflammation Models Analysed with Multi-Modal Mass Spectrometry Imaging

Int. J. Mol. Sci. 2024, 25(22), 12032; https://doi.org/10.3390/ijms252212032

A study from Matija’s PhD on the application of Reactive Gas Cluster Ion Beams has been published in Analytical Chemistry.

Reactive Gas Cluster Ion Beams for Enhanced Drug Analysis by Secondary Ion Mass Spectrometry

DOI: 10.1021/acs.analchem.4c02144

Our collaboration with Prof Richard Curry results in a publication in the journal Advanced Engineering Materials:

A High-Resolution Versatile Focused Ion Implantation Platform for Nanoscale Engineering

Adv. Eng. Mater., 25: 2300889. https://doi.org/10.1002/adem.202300889

We have co-authored the following paper led by Prof Satoka Aoyagi and her group at Seikei University, Japan.

Quantitative and Qualitative Analyses of Mass Spectra of OEL Materials by Artificial Neural Network and Interface Evaluation: Results from a VAMAS Interlaboratory Study

Open Access

Mass spectrometric imaging of brain tissue by time-of-flight secondary ion mass spectrometry – How do polyatomic primary beams C60+, Ar2000+, water-doped Ar2000+ and (H2O)6000+ compare?

Irma Berrueta Razo, Sadia Sheraz (née Rabbani), Alex Henderson, Nicholas P. Lockyer and John C. Vickerman
Rapid Commun. Mass Spectrom. 29 (2015) 1851–1862

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SIMS—A precursor and partner to contemporary mass spectrometry
John C. Vickerman and Nicholas Winograd
International Journal of Mass Spectrometry (2014)

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Publication:

ToF-SIMS as tool for profiling lipids in cancer and other diseases
J.L. Denbigh and N.P. Lockyer
Materials Science and Technology (2014)

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