Applications are invited for a cross-faculty BBSRC DTP studentship entitled: Imaging inflammatory changes in tissues by mass spectrometry
This project will focus on the use of mass spectrometry imaging of biological tissues to explore and further develop their capabilities in the context of inflammation research. Inflammation is central to progression and outcome of a wide range of important conditions including stroke, cancer, Alzheimer’s disease.
Details of the project, application process and eligibility requirements can be found here. Eligible applicants should contact the primary supervisor Adam.McMahon@manchester.ac.uk before making a formal application (deadline 22 Jan 2021)
We are looking for PhD students to join the group and work in the following areas:
- Fundamentals of keV ion beam interactions with surfaces or laser photons with sputter neutrals.
- Applications of Mass Spectrometry Imaging (SIMS, MALDI, DESI, LAESI) in materials and biological sciences.
- Development of methodologies for analysis and data processing in Mass Spectrometry Imaging.
If you are seeking support for funding applications or have funding already secured please contact Nick.Lockyer@manchester.ac.uk.
We have started a collaboration with the Biological Mass Spectrometry theme of the Rosalind Franklin Institute, led by Profs. Josephine Bunch and Zoltan Takats. This aims to develop new capabilities for mass specrometry imaging using SIMS and laser post-ionisation. We welcome back Dr Sadia Sheraz to the group to lead the experiments at the Photon Science Institute.
The Rosalind Franklin Institute is a new national institute, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology development.
EPSRC have funded a new MALDI imaging instrument through their strategic equipment call. The grant, worth £810 k will allow investment in the latest MALDI-ToF technology, enabling us to establish a facility serving internal and external users. The instrument complements the University’s world-leading mass spctrometry imaging capabilities including ToF-SIMS, Nano-SIMS, DESI-MS and LAESI-MS. The Facility will be managed through the Michael Barber Centre for Collaborative Mass Spectrometry.
Congratulations to Samar on the award of her PhD. Her thesis entitled ‘Detection and localisation of drug molecules in biological samples using secondary ion mass spectrometry (SIMS)’ was co-supervised by Dr Katie Moore and employed both ToF-SIMS and NanoSIMS.
Christmas came early this week at SARC with the delivery of our new J105 Instrument. Thanks to the hard work of the guys from Ionoptika Ltd it was assembled and at vacuum in 48h.
At the SIMS 22 International Conference in Kyoto in Oct 2019, Nick was elected by delegates onto the International Committee. The next conference, SIMS 23 will be held in Minneapolis, USA in 2021.
The group were well-represented at the 22nd International Conference on SIMS in Kyoto. Danielle, John Medland, Alex and Nick gave presentations.
We welcome a new PhD student, Matija Lagator from Serbia. Matija will work on the new J105-SIMS instrument. His project is entitled ‘Development of Novel High Energy Cluster Ion Beam Methodology for Molecular Analysis and Imaging’.
UKRI/The Faraday Institution have funded a project led by Dr Robert Weatherup (Diamond Manchester Research Fellow)
“What lies beneath? – new multimodal platforms for operando characterisation of buried interfaces in working batteries.”
The principal goal of this proposal is to develop new in-situ and operando platforms including ToF-SIMS, NAPXPS and HAXPES that will enable characterisation of buried interfaces in working batteries.
A BBSRC Flexible Talent Mobility Award to Dr Jolanda van Munster (School of Chemistry & MIB) and Dr Sadia Sheraz (School of Materials) will allow us to extend our SIMS research into plant matter. The project entitled “Correlative mass-spectrometry imaging for nanoscale structural insight into plant biomass for food and biotechnology” is in collaboration with Dr Katie Moore (School of Materials), Prof Richard Ward (University of São Paulo-Ribeirão Preto, Brazil) and Rothamsted Research Ltd.
The School of Chemistry at the University of Manchester have awarded Nick Lockyer a Chair in Physical Chemistry.
Nick came to the University (then UMIST) to read Chemistry in the late 1980s and continued to study for a PhD in Laser Ionisation Mass Spectrometry of Biomolecules, awarded in 1996. His postdoctoral research involved the development of the Biotof, an imaging ToF-SIMS instrument, with a focus on laser post-ionisation, sputtered neutral mass spectrometry (SNMS).
He was awarded a Leverhulme Special Research Fellowship to further develop the Biotof as a Chemical Microscope, following which he was appointed lecturer in Chemistry. Nick briefly moved to the School of Chemical Engineering and Analytical Science (CEAS), during the merger of UoM and UMIST in 2004, before moving back to Chemistry in 2011. With his research group in the Manchester Institute of Biotechnology (MIB), and also the Photon Science Institute (PSI), he has explored a range of imaging mass spectral modalities in the area of biology and biomaterials, together with technique and instrument development.
As the result of successful bids to EPSRC and the Royce Institute he was awarded a major grant to replace the Ionoptika J105 3D Chemical Imager with a new instrument. This will involve consolidating the research group in the PSI providing opportunities to further explore advanced materials and photonic approaches to mass spectrometry.
Funding from the Sao Paulo Research Foundation “FAPESP” and the University of Manchester for a new collaboration with Dr Jolanda van Munster, BBSRC research fellow in the Manchester Institute of Biotechnology (MIB) and Prof. Richard John Ward, group leader of the Protein Biochemistry and Biophysics Laboratory, University of São Paulo-Ribeirão Preto.
The aim is to bring together expertise in protein engineering and polysaccharide mass spectrometry to enhance understanding of cell wall architecture at the micrometer scale to guide enzymatic deconstruction of lignocellulose for enhanced biofuel production.
Congratulations to Huriyyah on the award of her PhD! Her thesis is entitled ‘New Capabilities for Molecular Surface and in-depth Analysis with Cluster Secondary Ion Mass Spectrometry’. The project was co-supervised by Prof Mike Turner at the Organic Materials Innovation Centre.