Dr Helen Kotze

Helen Kotze

Research Student

helen.kotze @ postgrad.manchester.ac.uk
  • PhD in Systems Biology of Chemotherapy in Hypoxia Environments (2008-present)
  • MChem Chemistry with Nanotechnology, University of Hull, UK (2004-2008)

Research

Hypoxia is found in solid cancerous tumours and associated poor patient prognosis. Hypoxia within tumours inhibits the anti-cancer treatment strategies such as chemotherapy from being completely effective, and it is suspected that multiple mechanisms contribute to the resistance. This project applies the multidisciplinary method of systems biology to determine the underlying mechanisms associated with hypoxia induced chemoresistance towards the commonly used chemotherapeutic doxorubicin. I aim to identify metabolic mechanisms that contribute to chemoresistance using mass spectrometry techniques GC-MS, UHPLC-MS and imaging ToF-SIMS.

Publications

4 Evaluating the challenges associated with time-of-flight secondary ion mass spectrometry for metabolomics using pure and mixed metabolites
John S. Fletcher, Helen L. Kotze, Emily G. Armitage, Nicholas P. Lockyer, John C. Vickerman
Metabolomics 9 (2013) 535-544
3 Imaging of metabolites using secondary ion mass spectrometry
Emily G. Armitage, Helen L. Kotze, Nicholas P. Lockyer
Metabolomics 9 (2013) 102-109
2 ToF-SIMS as a tool for metabolic profiling small biomolecules in cancer systems
Helen L. Kotze, Emily G. Armitage, John S. Fletcher, Alex Henderson, Kaye J. Williams, Nicholas P. Lockyer and John C. Vickerman
Surf. Interface Anal. 45 (2013) 277-281
1 Time-of-flight SIMS as a novel approach to unlocking the hypoxic properties of cancer
Emily G Armitage, Helen L Kotze, John S Fletcher, Alex Henderson, Kaye J Williams, Nicholas P Lockyer and John C Vickerman
Surf. Interface Anal. 45 (2013) 282-285

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