Emily Armitage

sEmily Armitage

Research Student

emily.armitage @ postgrad.manchester.ac.uk
  • PhD in Systems Biology of HIF Metabolism in Cancer (2008-present)
  • BSc in Biology, University of Sheffield, 2005-2008.

Hypoxia-inducible factor -1 (HIF-1) is a transcription factor that is activated under low oxygen tension and is commonly found in tumours. The main research objective is the application of a systems biology approach to investigate the effect of HIF-1 on the metabolome of cancer cells. This involves the development and application of experimental methodologies for metabolomic studies of cancer cells and tissues with hypoxic properties. Time of flight-secondary ion mass spectrometry (ToF-SIMS), gas and liquid chromatography mass spectrometry (GC/LC-MS) and Fourier transform infrared (FT-IR) spectroscopy are being employed alongside pharmaceutical techniques in cell and tissue culture to determine the metabolic properties of hypoxic cancer cells and tissues to determine the effect of HIF-1.

Publications

4 Evaluating the challenges associated with time-of-flight secondary ion mass spectrometry for metabolomics using pure and mixed metabolites
John S. Fletcher, Helen L. Kotze, Emily G. Armitage, Nicholas P. Lockyer, John C. Vickerman
Metabolomics 9 (2013) 535-544
3 Imaging of metabolites using secondary ion mass spectrometry
Emily G. Armitage, Helen L. Kotze, Nicholas P. Lockyer
Metabolomics 9 (2013) 102-109
2 ToF-SIMS as a tool for metabolic profiling small biomolecules in cancer systems
Helen L. Kotze, Emily G. Armitage, John S. Fletcher, Alex Henderson, Kaye J. Williams, Nicholas P. Lockyer and John C. Vickerman
Surf. Interface Anal. 45 (2013) 277-281
1 Time-of-flight SIMS as a novel approach to unlocking the hypoxic properties of cancer
Emily G Armitage, Helen L Kotze, John S Fletcher, Alex Henderson, Kaye J Williams, Nicholas P Lockyer and John C Vickerman
Surf. Interface Anal. 45 (2013) 282-285